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Appears in:
Pages: 5894-5899
Publication year: 2011
ISBN: 978-84-615-3324-4
ISSN: 2340-1095

Conference name: 4th International Conference of Education, Research and Innovation
Dates: 14-16 November, 2011
Location: Madrid, Spain

DAPOXETINE: AN EXCITING JOURNEY THROUGH RETROSYNTHETIC ANALYSIS

M.V. de Paz, A. Alcudia, C. Ferris

University of Seville (SPAIN)
Reducing the high University dropout rate in Europe remains a challenge currently pending across the continent and particularly in Spain. Although the average level of knowledge imparted by the Spanish University is 'worthy', “Cátedra UNESCO” warns that the University abandons in Spain (30%) almost double EU average (16%, data referred to the fifteen countries that formed the EU before extension).
With these data in mind, we can be attributed part of the intolerable dropout in Spain to the 'passivity' and 'stiffness' of University teaching method leading to doing away with the enthusiasm of the students. It is therefore essential changing our old-fashion way of teaching and leading their University educational period. The successful implementation of the European Higher Education Area may be useful to achieve a significant reduction in dropout data.

The aim of “Advanced Medicinal Chemistry” course (last year of Pharmacy Degree, University of Seville, Spain) is to train the students in “retrosynthetic” procedures that “constitute the basis of a general logic of synthetic planning which was developed and demonstrated in practice...” applied to commercially available drug synthesis. The students were then satisfactorily prepared to explore and design basic organic synthesis schemes, a talent that only can be learnt with instruction and practice.

An alternative approach to learn retrosynthetic analysis through problem solving and collaborative learning is presented. Thus, a commercially available drug is used to illustrate the potential of Problem Based Learning (PBL) methodologies. Herein, the authors propose an easy way of practicing some fundamentals of retrosynthetic procedure by PBL system, focus on Dapoxetine, a selective serotonin reuptake inhibitor drugs (SSRI) as the target molecule used in the treatment of premature ejaculation (PE).

References:
1. Warren, S.; Wyatt, P. Organic Synthesis: The Disconnection Approach. 2nd Edition, 2008, Chichester (UK): John Wiley & Sons,
2. Nobel Lecture of E. J. Corey, 1990.
http://nobelprize.org/nobel_prizes/chemistry/laureates/1990/corey-lecture.pdf [06-21-2010].
3. Uden, L.; Beaumont, C. (Eds.) Technology and Problem-Based Learning, 2006, London (UK): Information Science Publishing,
4. Clouston, T.; Westcott, L.; Whitcombe, S.; Riley, J.; Matheson, R. (Eds.) Problem-Based Learning in Health and Social Care, 2010, Chichester, UK, Wiley-Blackwell Publishing Ltd.
5. Blumenfeld, P.C.; Soloway, E.; Marx, R.W.; Krajcik, J.S.; Guzdial, M.; Palincsar, A. Motivating Project-Based Learning: Sustaining the Doing, Supporting the learning, In Fogarty R. (Ed) Problem Based Learning. A Collection of Articles, 1998, California, USA, Corwin Press.
@InProceedings{DEPAZ2011DAP,
author = {de Paz, M.V. and Alcudia, A. and Ferris, C.},
title = {DAPOXETINE: AN EXCITING JOURNEY THROUGH RETROSYNTHETIC ANALYSIS},
series = {4th International Conference of Education, Research and Innovation},
booktitle = {ICERI2011 Proceedings},
isbn = {978-84-615-3324-4},
issn = {2340-1095},
publisher = {IATED},
location = {Madrid, Spain},
month = {14-16 November, 2011},
year = {2011},
pages = {5894-5899}}
TY - CONF
AU - M.V. de Paz AU - A. Alcudia AU - C. Ferris
TI - DAPOXETINE: AN EXCITING JOURNEY THROUGH RETROSYNTHETIC ANALYSIS
SN - 978-84-615-3324-4/2340-1095
PY - 2011
Y1 - 14-16 November, 2011
CI - Madrid, Spain
JO - 4th International Conference of Education, Research and Innovation
JA - ICERI2011 Proceedings
SP - 5894
EP - 5899
ER -
M.V. de Paz, A. Alcudia, C. Ferris (2011) DAPOXETINE: AN EXCITING JOURNEY THROUGH RETROSYNTHETIC ANALYSIS, ICERI2011 Proceedings, pp. 5894-5899.
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